Fig. 6. The dominant elements, as upstream mechanical checkpoints, regulate YAP/TAZ localization in cell response to mechanical stimuli. In cells exposed to mechanical cues, YAP/TAZ localization (nuclear or cytoplasm) regulated through changes in the adhesion sites (1), cytoskeletal elements (2), the Rho signaling pathway (3), and nucleus deformation (4) (Reprinted with permission, Elsevier, for citation see [60]).